(TAXOTERE E METFORMINA ) TAXOMET: A French prospective multicenter randomized controlled phase II study comparing docetaxel plus metformin versus docetaxel plus placebo in mCRPC.

APESAR DO BENEFÍCIO EM SOBREVIDA SER "END POINT" SECUNDÁRIO , APRESENTOU-SE NO BRAÇO DO TAXO-MET 24,6 MESES X 19,7 MESES TAXOTERE ISOLADO , IMPORTANTE QUE ERAM NÃO PACIENTES DIABETICOS , SEM HIPOGLICEMIA , E COM "END POINT" PRIMÁRIO DE REDUÇÃO DE PSA TOTAL EM 66% 














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Diagnostic value of circulating free DNA for the detection of EGFR mutation status in NSCLC: a systematic review and meta-analysis

http://www.nature.com/articles/srep06269 Abstract Epidermal growth factor receptor (EGFR) mutation is a reliable and sensitive biomarker for EGFR-TKI therapy in non-small-cell lung cancer (NSCLC). However, detection of EGFR mutation in tissues has obvious limitations. Circulating free DNA (cfDNA) has been reported as an alternative approach for the detection of EGFR mutations. This systematic review and meta-analysis was designed to assess the diagnostic performance of cfDNA, compared with tissues. True-positive (TP), false-positive (FP), false-negative (FN), and true-negative (TN) values were extracted or calculated for each study. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated. A summary receiver operating characteristic curve (SROC) and area under curve (AUC) were used to evaluate the overall diagnostic performance. 20 eligible studies involving 2012 cases were included in this m...
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