Neratinib + capecitabine versus lapatinib + capecitabine in patients with HER2+ metastatic breast cancer previously treated with ≥ 2 HER2-directed regimens: Findings from the multinational, randomized, phase III NALA trial.



NERATINIB + CAPECITABINA SE DEMOSTROU SUPERIOR A COMBINAÇÃO DE LAPATINIB + CAPECITABINA , EM PACIENTES HER 2+ 3 , COM MAIS DE LINHAS DE TRATAMENTO PRÉVIOS COM (PERTUZ, TRAST, TDM1,OU MESMO NAS COMBINAÇÕES ANTI HER2 . APESAR DA DIARREIA NÃO TER SIDO FATOR LIMITANTE MAS EM MAIOR EXPRESSÃO NO SUBGRUPO ( NERA-CAP) , TEVE MAIOR PENETRAÇÃO NO SNC COM ATRASO NAS INTERVENÇÕES DE SNC COM RADIOT OU CIRURGIA
















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