A randomized phase III trial of systemic therapy plus early local therapy versus systemic therapy alone in women with de novo stage IV breast cancer: A trial of the ECOG-ACRIN Research Group (E2108)

Na duvida postei primeiro o comentário da Julie white ,  sobre Seema Khan , fica Realmente a questão sera que não vale a pena operar pacientes com Doença metastática De Novo, deixarei algumas urls, do Pubmed para discussão :

Tosello G, Torloni MR, Mota BS, Neeman T, Riera R. Breast surgery for metastatic breast cancer. Cochrane Database Syst Rev. 2018;3(3):CD011276. Published 2018 Mar 15. doi:10.1002/14651858.CD011276.pub2

Thomas A, Khan SA, Chrischilles EA, Schroeder MC. Initial Surgery and Survival in Stage IV Breast Cancer in the United States, 1988-2011. JAMA Surg. 2016;151(5):424‐431. doi:10.1001/jamasurg.2015.4539

Lane WO, Thomas SM, Blitzblau RC, et al. Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer: Contemporary Practice Patterns and Survival Analysis. Ann Surg. 2019;269(3):537‐544. doi:10.1097/SLA.0000000000002621


Xiong Z, Deng G, Wang J, et al. Could local surgery improve survival in de novo stage IV breast cancer?. BMC Cancer. 2018;18(1):885. Published 2018 Sep 11. doi:10.1186/s12885-018-4767-xLin Y, Huang K, Zeng Q, Zhang J, Song C. Impact of breast surgery on survival of patients with stage IV breast cancer: a SEER population-based propensity score matching analysis. PeerJ. 2020;8:e8694. Published 2020 Mar 18. doi:10.7717/peerj.8694




































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