Abstrato Apesar do uso generalizado e de um mecanismo de ação conhecido para os inibidores de CDK4/6 em combinação com a terapia endócrina, as características da evolução da doença e os determinantes da resposta terapêutica no cenário do mundo real permanecem obscuros. Aqui, uma coorte de pacientes tratados com regimes combinados de tratamento padrão foi utilizada para explorar características da doença e determinantes da sobrevida livre de progressão (PFS) e da sobrevida global (SG). Nesta coorte de 280 pacientes, >90% dos pacientes foram tratados com palbociclib em combinação com um inibidor da aromatase (IA) ou fulvestrant (FUL). A maioria desses pacientes apresentava escores modificados de Scarff-Bloom-Richardson (SBR) e imuno-histoquímica de ER, HER2 e PR. Tanto o escore SBR quanto a falta de expressão de PR foram associados a PFS mais curta em pacientes tratados com combinações de IA e permaneceram significativos em análises multivariadas (HR = 3,...
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