Resection of liver metastases in patients with breast cancer: Survival and prognostic factors
http://www.sciencedirect.com/science/article/pii/S0748798312003046?np=y
Resection of liver metastases in patients with breast cancer: Survival and prognostic
factors
G.A.M. van Walsum a,*, J.A.M. de Ridder b, C. Verhoef c, K. Bosscha d, T.M. van Gulik e, E.J. Hesselink f, T.J.M. Ruers g, M.P. van den Tol h, I.D. Nagtegaal i, M. Brouwers j, R. van Hillegersberg k, R.J. Porte l, A.M. Rijken m, L.J.A. Strobbe n, J.H.W de Wilt b
on behalf of the Dutch Liver Surgeons Group
factors
G.A.M. van Walsum a,*, J.A.M. de Ridder b, C. Verhoef c, K. Bosscha d, T.M. van Gulik e, E.J. Hesselink f, T.J.M. Ruers g, M.P. van den Tol h, I.D. Nagtegaal i, M. Brouwers j, R. van Hillegersberg k, R.J. Porte l, A.M. Rijken m, L.J.A. Strobbe n, J.H.W de Wilt b
on behalf of the Dutch Liver Surgeons Group
Abstract
Aims: Patients with breast cancer metastasized to the liver have a median survival of 4e33 months and treatment options are usually re-
stricted to palliative systemic therapy. The aim of this observational study was to evaluate the effectiveness and safety of resection of liver
metastases from breast cancer and to identify prognostic factors for overall survival.
Methods: Patients were identified using the national registry of histo- and cytopathology in the Netherlands (PALGA). Included were all patients who underwent resection of liver metastases from breast cancer in 11 hospitals in The Netherlands of the last 20 years. Study data were retrospectively collected from patient files.
Results: A total of 32 female patients were identified. Intraoperative and postoperative complications occurred in 3 and 11 patients, respectively. There was no postoperative mortality. After a median follow up period of 26 months (range, 0e188), 5-year and median overall survival after partial liver resection was 37% and 55 months, respectively. The 5-year disease-free survival was 19% with a me- dian time to recurrence of 11 months. Solitary metastases were the only independent significant prognostic factor at multivariate analysis.
Conclusion: Resection of liver metastases from breast cancer is safe and might provide a survival benefit in a selected group of patients. Especially in patients with solitary liver metastasis, the option of surgery in the multimodality management of patients with disseminated breast cancer should be considered.
! 2012 Elsevier Ltd. All rights reserved.
Keywords: Breast cancer; Hepatic metastases; Liver resection; Survival; Prognostic factors
Methods: Patients were identified using the national registry of histo- and cytopathology in the Netherlands (PALGA). Included were all patients who underwent resection of liver metastases from breast cancer in 11 hospitals in The Netherlands of the last 20 years. Study data were retrospectively collected from patient files.
Results: A total of 32 female patients were identified. Intraoperative and postoperative complications occurred in 3 and 11 patients, respectively. There was no postoperative mortality. After a median follow up period of 26 months (range, 0e188), 5-year and median overall survival after partial liver resection was 37% and 55 months, respectively. The 5-year disease-free survival was 19% with a me- dian time to recurrence of 11 months. Solitary metastases were the only independent significant prognostic factor at multivariate analysis.
Conclusion: Resection of liver metastases from breast cancer is safe and might provide a survival benefit in a selected group of patients. Especially in patients with solitary liver metastasis, the option of surgery in the multimodality management of patients with disseminated breast cancer should be considered.
! 2012 Elsevier Ltd. All rights reserved.
Keywords: Breast cancer; Hepatic metastases; Liver resection; Survival; Prognostic factors
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