A randomized phase III trial of systemic therapy plus early local therapy versus systemic therapy alone in women with de novo stage IV breast cancer: A trial of the ECOG-ACRIN Research Group (E2108)
Na duvida postei primeiro o comentário da Julie white , sobre Seema Khan , fica Realmente a questão sera que não vale a pena operar pacientes com Doença metastática De Novo, deixarei algumas urls, do Pubmed para discussão : Tosello G, Torloni MR, Mota BS, Neeman T, Riera R. Breast surgery for metastatic breast cancer. Cochrane Database Syst Rev. 2018;3(3):CD011276. Published 2018 Mar 15. doi:10.1002/14651858.CD011276.pub2 Thomas A, Khan SA, Chrischilles EA, Schroeder MC. Initial Surgery and Survival in Stage IV Breast Cancer in the United States, 1988-2011. JAMA Surg. 2016;151(5):424‐431. doi:10.1001/jamasurg.2015.4539 Lane WO, Thomas SM, Blitzblau RC, et al. Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer: Contemporary Practice Patterns and Survival Analysis. Ann Surg. 2019;269(3):537‐544. doi:10.1097/SLA.0000000000002621 Xiong Z, Deng G, Wang J, et al. Could local surgery improve survival in de novo stage IV breast cancer?. BMC
